ÌÇÐÄvlogÃÛÌÒ

Department of Surgery

  1. ÌÇÐÄvlogÃÛÌÒ of Medicine
  2. Departments
  3. Surgery
  4. Research
  5. Systems Onco-Immunology Lab

Systems Onco-Immunology Laboratory

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Systems Onco-Immunology Lab
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Systems Onco-Immunology Approaches
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ÌÇÐÄvlogÃÛÌÒ the Lab

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Under the direction of Hyun-Sung Lee, M.D., Ph.D., the Systems Onco-Immunology Laboratory (SOIL) develops and applies innovative multi-omics approaches to elucidate cancer-immune networks and inform the design of novel immunotherapy strategies. The lab was founded in 2015 by a legendary thoracic surgeon, Dr. David J. Sugarbaker. 

SOIL serves as a hub for translational oncology research in thoracic oncology and unites an interdisciplinary team of surgeons, medical oncologists, immunologists, and bioinformaticians. We also engage broadly with the scientific community and provide educational opportunities in systems onco-immunology.

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Systems Onco-Immunology Approaches

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Comprehensive, integrated approaches are employed to characterize both local and systemic immune responses and to define complex cellular networks at single-cell resolution. These platforms encompass technologies applicable to both tissue specimens and single-cell suspensions, including next-generation sequencing (NGS), mass spectrometry (MS), cytometry by time-of-flight (CyTOF), high-dimensional imaging mass cytometry (IMC), and single-cell multi-omics. Collectively, these methodologies have been leveraged to monitor responses to checkpoint immunotherapy, map dynamic immune changes within the host, and advance the development of personalized precision immunotherapy.

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Areas of Research

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Preclinical and clinical studies have produced expansive, data-rich atlases that enable in-depth characterization of anti-tumor immune responses and serve as a critical foundation for discovery in tumor immunology. Our research program leverages high-dimensional single-cell and spatial technologies within a comprehensive systems immunology framework.

By integrating these complementary platforms, we aim to elucidate the cellular and molecular architecture of immune responses in solid tumors, uncover actionable therapeutic targets, and develop robust prognostic and predictive biomarkers to guide clinical decision-making. Our overarching objective is to advance personalized cancer immunotherapy through a comprehensive, integrated systems immunology approach.

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In the News

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