Changyi Johnny Chen

Changyi Johnny Chen, M.D., Ph.D.

Professor and Director, Basic Science and Translational Labs

(713) 798-4401

Email

jchen@bcm.edu

Positions

Professor and Director, Basic Science and Translational Labs: ��vlog�� of Medicine

Molecular Surgery Endowed Chair: ��vlog�� of Medicine

Professor of Molecular and Cellular Biology: ��vlog�� of Medicine

Editor-in-Chief: Patient Preference and Adherence

Addresses

Alkek Building for Biomedical Research (Lab): One Baylor Plaza
R413
Houston, TX, 77021
United States

Education

PhD from Georgia Institute of Technology: 01/1996 - Atlanta, GA, United States

MS from The University of Texas at El Paso: 01/1991 - El Paso, TX, United States

Residency at Southeast University School of Medicine - Zhong-Da Hospital: 01/1987 - Nanjing, China, People's Rep

MD from Southeast University School of Medicine: 01/1982 - Nanjing, China, People's Rep

Honors & Awards

2018 Hans-Peter Krayenbuehl Memorial Award: International Academy of Cardiology

Inaugural Senior Member: National Academy of Inventors (NAI)

Professional Interests

Pancreatic cancer
Hyperuricemia and uric acid-lowering drug discoveries
LGA-PEI based nanotechnology drug delivery systems
Pancreatic cancer
ACE2 inhibitors and drug discoveries
Endothelial dysfunction and vascular disease
Angiogenesis
Atherosclerosis
Cardiovascular disease
Endothelial nitric oxide synthase
Hemodynamics
Vascular tissue engineering
Oxidative stress and antioxidants

Professional Statement

Dr. Chen's laboratory is actively conducting several basic science and translational research projects that are highly relevant to clinical cardiovascular disease and pancreatic cancer.

Cardiovascular risk factors and their molecular mechanisms in cardiovascular disease:
We are investigating the effects and the molecular mechanisms of several cardiovascular risk factors, including HIV protease inhibitors, the adipokine resistin, soluble CD40L, and uric acid, on biochemical pathways associated with endothelial cell functions. Some of the biochemical pathways under investigation are the endothelial nitric oxide synthase system, the oxidative stress system, and signal transduction pathways. We are carrying on these investigations using several experimental models, such as myographies, organ cultures, mouse models, human tissue samples, and different types of endothelial cells. Based on the molecular mechanisms we uncover, we develop effective therapeutic strategies to treat endothelial dysfunction and atherosclerosis.

Endothelial cell differentiation and angiogenesis:
We are studying the role played by and the molecular mechanisms of hemodynamic factors and several novel molecules on endothelial cells differentiated from embryonic stem cells and from bone marrow-derived stem cells. We are identifying key regulatory genes that trigger endothelial cell differentiation and promote stable angiogenesis. These findings can potentially be applied to the design of novel therapeutic strategies to treat ischemic tissues using genetically engineered endothelial cells. In addition, these studies may provide useful information to genetically engineer novel tissues for vascular grafts.

Pancreatic cancer:
We have been heavily involved in pancreatic cancer research programs for many years. We have several projects focusing on the role and on the mechanisms of several genes, such as microRNA 196a (miR-196a), X-inactive specific transcript (XIST), and Jude-2 in pancreatic cancer. Our comprehensive studies analyze human cancer specimens, clinical outcomes, established cell lines, a nude mouse model, and a genetically engineered mouse model of pancreatic cancer called the KPC model. We are developing LGA-PEI-based nanotechnology for molecular imaging and for specific drug and gene delivery, which has great potential clinical applications, such as molecular diagnostics and targeted therapies.

Drug discoveries:
We have been actively involved in drug discovery programs through high throughput screen libraries, focusing on novel xanthine oxidase (XO) inhibitors, which have potential clinical applications for the treatment of hyperuricemia-associated diseases. Recently, we also discover novel ACE2 inhibitors, which may have potential clinical application for the prevention or treatment of COVID-19 or other ACE2 related diseases.

Websites

eNOS Signal Pathways

��vlog�� of Medicine graduate starts Speratum CR to bring his own discovery to cancer patients

Dr. Chen Honored by International Academy of Cardiology

Videos

eNOS Signaling Pathways

Selected Publications

Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Surg. Res.. 2006 Jun 15; 133 (2) : 143-9.
Pubmed PMID: .
Conklin BS, Zhong DS, Zhao W, Lin PH, Chen C. " " J. Surg. Res.. 2002 Jan ; 102 (1) : 13-21.
Pubmed PMID: .
Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. " " J. Surg. Res.. 2005 Feb ; 123 (2) : 294-301.
Pubmed PMID: .
Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q. " " World J Surg. 2005 Mar ; 29 (3) : 293-6.
Pubmed PMID: .
Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. " " Tissue Eng.. ; 11 (41527) : 1535-52.
Pubmed PMID: .
Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C. " " Cancer. 2004 Nov 15; 101 (10) : 2341-50.
Pubmed PMID: .
Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen CJ. " " Med. Sci. Monit.. 2004 Aug ; 10 (8) : RA187-92.
Pubmed PMID: .
Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC. " " World J Surg. 2005 Mar ; 29 (3) : 339-43.
Pubmed PMID: .
Lin PH, Martin L, Matsuura JH, Wellons E, Bush RL, Terramani TT, Chen C, Lumsden AB. " " Cardiovasc Intervent Radiol. ; 26 (1) : 73-5.
Pubmed PMID: .
Cesarman E, Moore PS, Rao PH, Inghirami G, Knowles DM, Chang Y. " " Blood. 1995 Oct 1; 86 (7) : 2708-14.
Pubmed PMID: .
Rodriguez E, Rao PH, Ladanyi M, Altorki N, Albino AP, Kelsen DP, Jhanwar SC, Chaganti RS. " " Cancer Res.. 1990 Oct 1; 50 (19) : 6410-6.
Pubmed PMID: .
Lin PH, Bush RL, Chaikof EL, Chen C, Conklin B, Terramani TT, Brinkman WT, Lumsden AB. " " J. Vasc. Surg.. 2002 Sep ; 36 (3) : 500-6.
Pubmed PMID: .
Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. " " Am. J. Surg.. 2004 Dec ; 188 (6) : 690-7.
Pubmed PMID: .
Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C. " " Cardiovasc. Res.. 2006 Apr 1; 70 (1) : 146-57.
Pubmed PMID: .
Lin PH, Surowiec SM, Conklin B, Bush RL, Chen C, Chaikof EL, Lumsden AB. " " J. Endovasc. Ther.. 2000 Dec ; 7 (6) : 486-93.
Pubmed PMID: .
Lin PH, Bush RL, Nguyen L, Guerrero MA, Chen C, Lumsden AB. " " Vasc Endovascular Surg. ; 39 (2) : 135-42.
Pubmed PMID: .
Verma RS, Pulivarthi RH. " " J Ment Defic Res. 1991 Dec ; 35 : 548-50.
Pubmed PMID: .
Chen C, Li J, Mattar SG, Pierce GF, Aukerman L, Hanson SR, Lumsden AB. " " J. Surg. Res.. 1997 May ; 69 (2) : 300-6.
Pubmed PMID: .
Chen C, Hanson SR, Keefer LK, Saavedra JE, Davies KM, Hutsell TC, Hughes JD, Ku DN, Lumsden AB. " " J. Surg. Res.. 1997 Jan ; 67 (1) : 26-32.
Pubmed PMID: .
Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C. " " Surgery. 2005 Aug ; 138 (2) : 212-22.
Pubmed PMID: .
Ohashi R, Mu H, Yao Q, Chen C. " " Trends Cardiovasc. Med.. 2004 Jul ; 14 (5) : 187-90.
Pubmed PMID: .
Mu H, Ohashi R, Lin P, Yao Q, Chen C. " " Vasc Med. 2005 Feb ; 10 (1) : 37-44.
Pubmed PMID: .
Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE. " " J. Surg. Res.. 2004 Jun 15; 119 (2) : 130-7.
Pubmed PMID: .
Wu H, Yao Q, Lumsden A, Chen C. " " J. Surg. Res.. 2004 May 1; 118 (1) : 38-44.
Pubmed PMID: .
Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. " " Cardiovasc Drug Rev. 2004 ; 22 (4) : 309-19.
Pubmed PMID: .
Ye BH, Rao PH, Chaganti RS, Dalla-Favera R. " " Cancer Res.. 1993 Jun 15; 53 (12) : 2732-5.
Pubmed PMID: .
Sreekantaiah C, Rao PH, Xu L, Sacks PG, Schantz SP, Chaganti RS. " " Genes Chromosomes Cancer. 1994 Sep ; 11 (1) : 29-39.
Pubmed PMID: .
Liao D, Wang X, Lin PH, Yao Q, Chen CJ. " " J. Cell. Mol. Med.. 2009 Aug ; 13 (8) : 2736-43.
Pubmed PMID: .
Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. " " J. Am. Coll. Surg.. 2005 Jun ; 200 (6) : 820-30.
Pubmed PMID: .
Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C. " " J. Vasc. Surg.. 2004 Dec ; 40 (6) : 1216-22.
Pubmed PMID: .
Rodriguez E, Rao PH, Reuter V. " " Cancer Genet. Cytogenet.. 1992 Jul 15; 61 (2) : 207-9.
Pubmed PMID: .
Rao PH, Mathew S, Kelsen DP, Chaganti RS. " " Cancer Genet. Cytogenet.. 1995 Jun ; 81 (2) : 139-43.
Pubmed PMID: .
Chen C, Li J, Micko CJ, Pierce GF, Cunningham MR, Lumsden AB. " " J. Surg. Res.. 1998 Feb 15; 75 (1) : 35-41.
Pubmed PMID: .
Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. " " J. Cell. Mol. Med.. ; 9 (1) : 41343.
Pubmed PMID: .
Gaidano G, Hauptschein RS, Parsa NZ, Offit K, Rao PH, Lenoir G, Knowles DM, Chaganti RS, Dalla-Favera R. " " Blood. 1992 Oct 1; 80 (7) : 1781-7.
Pubmed PMID: .
Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q. " " Am. J. Surg.. 2005 Nov ; 190 (5) : 739-45.
Pubmed PMID: .
Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C. " " J. Surg. Res.. 2005 Jun 15; 126 (2) : 182-8.
Pubmed PMID: .
Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Acquir. Immune Defic. Syndr.. 2005 Sep 1; 40 (1) : 41617.
Pubmed PMID: .
Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. " " J. Surg. Res.. 2005 Jun 1; 126 (1) : 121-9.
Pubmed PMID: .
Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. " " J. Surg. Res.. 2005 Feb ; 123 (2) : 312-9.
Pubmed PMID: .
Fu W, Chai H, Yao Q, Chen C. " " J. Acquir. Immune Defic. Syndr.. 2005 Jun 1; 39 (2) : 152-8.
Pubmed PMID: .
Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C. " " J. Surg. Res.. 2006 Jun 15; 133 (2) : 89-94.
Pubmed PMID: .
Chen C, Halkos ME, Surowiec SM, Conklin BS, Lin PH, Lumsden AB. " " J. Surg. Res.. 2000 Jan ; 88 (1) : 26-33.
Pubmed PMID: .
Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C. " " Surgery. 2005 Sep ; 138 (3) : 464-73.
Pubmed PMID: .
Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Surg. Res.. 2005 Mar ; 124 (1) : 104-11.
Pubmed PMID: .
Nan B, Lin P, Lumsden AB, Yao Q, Chen C. " " Thromb. Res.. 2005 ; 115 (5) : 417-26.
Pubmed PMID: .
Ofenloch JC, Chen C, Hughes JD, Lumsden AB. " " Ann Vasc Surg. 1997 Jan ; 11 (1) : 62-7.
Pubmed PMID: .
Bush RL, Lin PH, Reddy PP, Chen C, Weiss VJ, Guinn G, Lumsden AB. " " Cardiovasc Surg. 2003 Jun ; 11 (3) : 179-84.
Pubmed PMID: .
Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Surg. Res.. 2004 May 1; 118 (1) : 83-90.
Pubmed PMID: .
Lin PH, Surowiec SM, Conklin B, Chen C, Bush R, Weiss VJ, Lumsden AB. " " J Vasc Interv Radiol. 2000 Jun ; 11 (6) : 785-91.
Pubmed PMID: .
Lin PH, Chen C, Surowiec SM, Conklin B, Bush RL, Lumsden AB. " " J. Vasc. Surg.. 2001 Mar ; 33 (3) : 621-7.
Pubmed PMID: .
Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C. " " J. Surg. Res.. 2004 Dec ; 122 (2) : 249-55.
Pubmed PMID: .
Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE. " " World J Surg. 2005 Mar ; 29 (3) : 297-305.
Pubmed PMID: .
Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Vasc. Surg.. 2005 May ; 41 (5) : 861-8.
Pubmed PMID: .
Lin PH, Chronos NA, Marijianowski MM, Chen C, Bush RL, Conklin B, Lumsden AB, Hanson SR. " " J Vasc Interv Radiol. 2003 May ; 14 (5) : 603-11.
Pubmed PMID: .
Yao Q, Compans RW, Chen C. " " Virology. 2001 Jun 20; 285 (1) : 128-37.
Pubmed PMID: .
Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C. " " Cardiovasc. Res.. 2004 Jul 1; 63 (1) : 168-75.
Pubmed PMID: .
Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Vasc. Surg.. 2003 Sep ; 38 (3) : 549-55; discuss.
Pubmed PMID: .
Ren Z, Yao Q, Chen C. " " Lab. Invest.. 2002 Mar ; 82 (3) : 245-55.
Pubmed PMID: .
Chen C, Conklin BS, Ren Z, Zhong DS. " " J. Surg. Res.. 2002 Jan ; 102 (1) : 22-30.
Pubmed PMID: .
Mitra AB, Rao PH, Pratap M. " " Cancer Genet. Cytogenet.. 1994 Aug ; 76 (1) : 56-8.
Pubmed PMID: .
Lin PH, Bush RL, Milas M, Terramani TT, Dodson TF, Chen C, Chaikof EL, Lumsden AB. " " Am. J. Surg.. 2003 Aug ; 186 (2) : 189-93.
Pubmed PMID: .
Morsy AH, Kulbaski M, Chen C, Isiklar H, Lumsden AB. " " J. Surg. Res.. 1998 Jan ; 74 (1) : 41496.
Pubmed PMID: .
Rao PH, Mathew S, Lauwers G, Rodriguez E, Kelsen DP, Chaganti RS. " " Diagn. Mol. Pathol.. 1993 Dec ; 2 (4) : 264-8.
Pubmed PMID: .
Chen C, Surowiec SM, Morsy AH, Ma M. " " Atherosclerosis. 2002 Jan ; 160 (1) : 103-14.
Pubmed PMID: .
Lin PH, Bush RL, Conklin BS, Chen C, Weiss VJ, Chaikof EL, Lumsden AB. " " J. Surg. Res.. 2002 Apr ; 103 (2) : 153-9.
Pubmed PMID: .
Ladanyl M, Heinemann FS, Huvos AG, Rao PH, Chen QG, Jhanwar SC. " " Hum. Pathol.. 1990 Dec ; 21 (12) : 1245-51.
Pubmed PMID: .
Lumsden AB, Chen C, Coyle KA, Ofenloch JC, Wang JH, Yasuda HK, Hanson SR. " " J. Vasc. Surg.. 1996 Nov ; 24 (5) : 825-33.
Pubmed PMID: .
Hughes JD, Chen C, Mattar SG, Someren A, Noe B, Suwyn CR, Lumsden AB. " " Ann Vasc Surg. 1996 Mar ; 10 (2) : 123-30.
Pubmed PMID: .
Chen C, Mattar SG, Lumsden AB. " " J. Surg. Res.. 1999 Mar ; 82 (1) : 17-23.
Pubmed PMID: .
Yao Q, Kuhlmann FM, Eller R, Compans RW, Chen C. " " AIDS Res. Hum. Retroviruses. 2000 Feb 10; 16 (3) : 227-36.
Pubmed PMID: .
Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. " " J. Surg. Res.. 2003 Nov ; 115 (1) : 82-91.
Pubmed PMID: .
Houldsworth J, Mathew S, Rao PH, Dyomina K, Louie DC, Parsa N, Offit K, Chaganti RS. " " Blood. 1996 Jan 1; 87 (1) : 25-9.
Pubmed PMID: .
Chen C, Ofenloch JC, Yianni YP, Hanson SR, Lumsden AB. " " J. Surg. Res.. 1998 Jul 1; 77 (2) : 119-25.
Pubmed PMID: .
Hughes JD, Mattar SG, Chen C, Someren A, Noe B, Suwyn CR, Lumsden AB. " " J. Surg. Res.. 1996 Feb 1; 60 (2) : 321-6.
Pubmed PMID: .
Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C. " " World J Surg. 2005 Mar ; 29 (3) : 276-80.
Pubmed PMID: .
Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. " " Ann Biomed Eng. 2005 Jun ; 33 (6) : 772-9.
Pubmed PMID: .
Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q. " " World J Surg. 2005 Mar ; 29 (3) : 271-5.
Pubmed PMID: .
Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q. " " World J Surg. 2005 Mar ; 29 (3) : 264-70.
Pubmed PMID: .
Zhang R, Li M, Chen C, Yao Q. " " Vaccine. 2004 Nov 25; 23 (2) : 139-47.
Pubmed PMID: .
Lin PH, Dodson TF, Bush RL, Weiss VJ, Conklin BS, Chen C, Chaikof EL, Lumsden AB. " " J. Vasc. Surg.. 2001 Dec ; 34 (6) : 1071-8.
Pubmed PMID: .
Chen C, Ku DN, Kikeri D, Lumsden AB. " " J. Surg. Res.. 1996 Feb 1; 60 (2) : 409-16.
Pubmed PMID: .
Lin PH, Kulbaski MJ, Terramani TT, Bush RL, Brinkman WT, Chen C, Conklin B, Lumsden AB. " " Am Surg. 2002 Oct ; 68 (10) : 865-70.
Pubmed PMID: .
Chen C, Hughes JD, Mattar SG, Ku DN, Lumsden AB. " " J. Surg. Res.. 1997 Jan ; 67 (1) : 106-12.
Pubmed PMID: .
Nanus DM, Lynch SA, Rao PH, Anderson SM, Jhanwar SC, Albino AP. " " Oncogene. 1991 Nov ; 6 (11) : 2105-11.
Pubmed PMID: .
Doan LX, Li M, Chen C, Yao Q. " " Rev. Med. Virol.. ; 15 (2) : 75-88.
Pubmed PMID: .
Lin PH, Bush RL, Chen C, Lumsden AB. " " Semin Vasc Surg. 2004 Mar ; 17 (1) : 57-63.
Pubmed PMID: .

to edit your profile

����vlog����