Graeme Mardon

Graeme Mardon, Ph.D.

James R. Davis Chair in Pathology and Immunology

(713) 798-8731

Email

gmardon@bcm.edu

Positions

James R. Davis Chair in Pathology and Immunology: ��vlog�� of Medicine
Houston, Texas, United States

Professor: Molecular and Human Genetics
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Co-Director: Graduate Program in Molecular and Human Genetics
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Professor: Program in Developmental Biology
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Professor: Neuroscience
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Professor: Program in Integrative Molecular and Biomedical Sciences
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Professor: Ophthalmology
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Education

BS from Haverford College: 01/1980 - Haverford, PA, United States

PhD from Massachusetts Institute Of Technology: 01/1990 - Cambridge, MA, United States

Post-Doctoral Fellowship at University Of California, Berkeley: 01/1994 - Berkeley, CA, United States

Honors & Awards

Best Lecturer, 8-Stranded Beta-Barrel Jelly Roll Awards, ��vlog�� of Medicine: ��vlog�� of Medicine (01/2008)

James M. Barr Award for Outstanding Retina Research Achievement: (01/2006)

James M. Barr Award for Outstanding Retina Research Achievement: (01/2002)

Marc Dresden Excellence in Graduate Education Award, ��vlog�� of Medicine: ��vlog�� of Medicine (01/2001)

Brochstein Award for Outstanding Achievement in Retina Research: (01/1999)

Professional Interests

Retinal cell fate determination, development, and function in Drosophila and vertebrates

Professional Statement

The primary goal of our research is to understand the molecular mechanisms of retinal development with the ultimate goal of improving our ability to prevent, diagnose and treat human retinal disease. To this end, we are using the fruit fly Drosophila melanogaster as a model system to identify and determine the function of conserved genes required for normal retinal development. In spite of substantial differences between vertebrate and insect retinal morphology, genetic mechanisms of retinal development have been conserved for more than 500 million years. Thus, study of the molecular and genetic pathways controlling Drosophila eye development has provided a valuable set of tools with which to decipher the development and function of the vertebrate retina.

Our current research begins with the observation that the Epidermal Growth Factor Receptor (Egfr, a receptor tyrosine kinase) signaling pathway is both necessary and sufficient to trigger the differentiation of nearly all cell types in the Drosophila retina. This finding posed the question of how activation of a single pathway could trigger the differentiation of more than ten different cell types in the same tissue at the same time during development. Given the fundamental importance of Egfr signaling throughout higher eukaryotes in cancer, cell differentiation, proliferation and survival, it is of broad significance to unravel this conundrum. To this end, we have generated extensive single cell RNA-sequencing data on multiple stages of the developing and adult Drosophila eye, as well single cell chromatin accessibility data (ATAC-seq), and whole eye disc ChIP-seq for Pointed, the nuclear effector of Egfr signaling. Integration and mining of these data has led to multiple hypotheses of how the Egfr pathway is reiteratively used to regulate retinal cell fate determination which we are currently testing. In addition, these data have revealed many other new insights into Drosophila eye development with unprecedented resolution and provide a fertile starting point for myriad studies.

Websites

Department of Molecular and Human Genetics

Genetics & Genomics Graduate Program

Mardon Lab

Selected Publications

Roman D, Zhong H, Yaklichkin S, Chen R, Mardon G. " " Exp Eye Res. 2018 Jul 25; 176 : 219-226.
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Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R.. " " J Cell Biol. 2018 Aug 6; 217 (8) : 2851-2865.
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Retshabile G, Mlotshwa BC, Williams L, Mwesigwa S, Mboowa G, Huang Z, Rustagi N, Swaminathan S, Katagirya E, Kyobe S, Wayengera M, Kisitu GP, Kateete DP, Wampande EM, Maplanka K, Kasvosve I, Pettitt ED, Matshaba M, Nsangi B, Marape M, et al. " " Am J Hum Genet. 2018 May 3; 102 (5) : 731-743.
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Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G.. " " FEBS J.. 2016 Aug ; 283 (15) : 2754-66.
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Jin M, Mardon G.. " " Sci Rep.. 2016 Mar 16; 6 (23228)
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Zhong H, Eblimit A, Moayedi Y, Boye SL, Chiodo VA, Chen Y, Li Y, Nichols RM, Hauswirth WW, Chen R, Mardon G. " " Gene Ther. 2015 Aug ; 22 : 619-627.
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Zhong H, Chen Y, Li Y, Chen R, Mardon G. " " Sci Rep.. 2015 Jul ; 5 : 9731.
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Jusiak B, Wang F, Karandikar UC, Kwak SJ, Wang H, Chen R, Mardon G. " " Genom Data. 2014 Dec 1; 2 : 153-5.
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Yang Z, Zhong H, Chen J, Zhang X, Zhang H, Luo X, Xu S, Chen H, Lu D, Han Y, Li J, Fu L, Qi X, Peng Y, Xiang K, Lin Q, Guo Y, Li M, Cao X, Zhang Y, Liao S, Peng Y, Zhang L, Guo X, Dong S, Liang F, Wang J, Willden A, Seang Aun H, Serey B., et al. " " Mol Biol Evol.. 2016 May ; 33 (5) : 1177-87.
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Pepple KL, Anderson AE, Frankfort BJ, Mardon G. " " Genetics. 2007 Jan ; 175 (1) : 125-41.
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Gaul U, Mardon G, Rubin GM. " " Cell. 1992 Mar 20; 68 (6) : 1007-19.
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Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G. " " Mech. Dev.. 2001 Apr ; 102 (41276) : 169-79.
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Loosli F, Mardon G, Wittbrodt J. " " Mech. Dev.. 2002 Mar ; 112 (41276) : 203-6.
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Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Mardon G, Chen R.. " " Exp Eye Res.. 2018 Jan ; 166:120-130.
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Inoue Y, Mito T, Miyawaki K, Matsushima K, Shinmyo Y, Heanue TA, Mardon G, Ohuchi H, Noji S. " " Mech. Dev.. 2002 May ; 113 (2) : 141-8.
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Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Moayedi Y, Mardon G, Chen R.. " " Exp Eye Res.. 2018 Jun ; 171:119.
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Davis RJ, Shen W, Sandler YI, Amoui M, Purcell P, Maas R, Ou CN, Vogel H, Beaudet AL, Mardon G. " " Mol. Cell. Biol.. 2001 Mar ; 21 (5) : 1484-90.
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Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ. " " Mech. Dev.. 2002 Feb ; 111 (41276) : 75-87.
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Chen R, Amoui M, Zhang Z, Mardon G. " " Cell. 1997 Dec 26; 91 (7) : 893-903.
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Mardon G, Solomon NM, Rubin GM. " " Development. 1994 Dec ; 120 (12) : 3473-86.
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Tavsanli BC, Pappu KS, Mehta SQ, Mardon G. " " Genesis. 2001 Nov ; 31 (3) : 130-6.
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Karandikar UC, Jin M, Jusiak B, Kwak S, Chen R, Mardon G. " " PLoS One. 2014 Jul 24; 9 (7) : e102143.
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Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G. " " Development. 2004 May ; 131 (9) : 2183-94.
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Davis RJ, Tavsanli BC, Dittrich C, Walldorf U, Mardon G. " " Dev. Biol.. 2003 Jul 15; 259 (2) : 272-87.
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Haase Gilbert E, Kwak SJ, Chen R, Mardon G. " " PLoS ONE. 2013 ; 8 (4) : e60908.
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Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G. " " Development. 2005 Jun ; 132 (12) : 2895-905.
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Mardon G, Mosher R, Disteche CM, Nishioka Y, McLaren A, Page DC. " " Science. 1989 Jan 6; 243 (4887) : 78-80.
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Atkins M, Jiang Y, Sansores-Garcia L, Jusiak B, Halder G, Mardon G. " " PLoS Genet.. 2013 ; 9 (8) : e1003731.
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Shen W, Mardon G. " " Development. 1997 Jan ; 124 (1) : 45-52.
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Zhong H, Chen Y, Li Y, Chen R, Mardon G.. " " Sci Rep. 2015 Jul 15; 5:9731.
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Wang H, Chen X, Dudinsky L, Patenia C, Chen Y, Li Y, Wei Y, Abboud EB, Al-Rajhi AA, Lewis RA, Lupski JR, Mardon G, Gibbs RA, Perkins BD, Chen R. " " Mol. Vis.. 2011 ; 17 : 3529-40.
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Rayapureddi JP, Kattamuri C, Steinmetz BD, Frankfort BJ, Ostrin EJ, Mardon G, Hegde RS. " " Nature. 2003 Nov 20; 426 (6964) : 295-8.
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Jin M, Jusiak B, Bai Z, Mardon G. " " PLoS ONE. 2013 ; 8 (3) : e58818.
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Mardon G, Varmus HE. " " Cell. 1983 Mar ; 32 (3) : 871-9.
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Pappu KS, Mardon G. " " Int. J. Dev. Biol.. 2004 ; 48 (41495) : 913-24.
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Ostrin EJ, Li Y, Hoffman K, Liu J, Wang K, Zhang L, Mardon G, Chen R. " " Genome Res.. 2006 Apr ; 16 (4) : 466-76.
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Jin M, Aibar S, Ge Z, Chen R, Aerts S, Mardon G.. " " Dev Biol.. 2016 Jul 1; 415 (1) : 157-67.
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Schaeffer E, Smith D, Mardon G, Quinn W, Zuker C. " " Cell. 1989 May 5; 57 (3) : 403-12.
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Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM. " " Mol. Cell. Biol.. 1985 Apr ; 5 (4) : 831-8.
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Chen R, Mardon G. " " Dev. Biol.. 2005 Jun 15; 282 (2) : 285-93.
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Jusiak B, Abulimiti A, Haelterman N, Chen R, Mardon G. " " PLoS ONE. 2012 ; 7 (12) : e50776.
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Pappu KS, Chen R, Middlebrooks BW, Woo C, Heberlein U, Mardon G. " " Development. 2003 Jul ; 130 (13) : 3053-62.
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Davis RJ, Shen W, Heanue TA, Mardon G. " " Dev. Genes Evol.. 1999 Sep ; 209 (9) : 526-36.
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Davis RJ, Harding M, Moayedi Y, Mardon G. " " Genesis. 2008 Apr ; 46 (4) : 205-13.
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Davis RJ, Pesah YI, Harding M, Paylor R, Mardon G. " " Genesis. 2006 Feb ; 44 (2) : 84-92.
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Mardon G, Luoh SW, Simpson EM, Gill G, Brown LG, Page DC. " " Mol. Cell. Biol.. 1990 Feb ; 10 (2) : 681-8.
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Li Y, Wang H, Peng J, Gibbs RA, Lewis RA, Lupski JR, Mardon G, Chen R. " " Invest. Ophthalmol. Vis. Sci.. 2009 Mar ; 50 (3) : 1336-43.
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Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Nageeb M. " " Nat. Genet.. 2012 Jul 29; 44 (9) : 1035-9.
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Wang H, den Hollander AI, Moayedi Y, Abulimiti A, Li Y, Collin RW, Hoyng CB, Lopez I, Abboud EB, Al-Rajhi AA, Bray M, Lewis RA, Lupski JR, Mardon G, Koenekoop RK, Chen R. " " Am. J. Hum. Genet.. 2009 Mar ; 84 (3) : 380-7.
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Eblimit A, Zaneveld SA, Liu W, Thomas K, Wang K, Li Y, Mardon G, Chen R.. " " Exp Eye Res.. 2018 Aug ; 173 : 32-43.
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Li Y, Jiang Y, Chen Y, Karandikar U, Hoffman K, Chattopadhyay A, Mardon G, Chen R.. " " Dev Biol.. 2013 Sep 1; 381 (1) : 50-61.
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Purcell P, Oliver G, Mardon G, Donner AL, Maas RL. " " Gene Expr. Patterns. 2005 Dec ; 6 (1) : 110-8.
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Wiszniewski W, Lewis RA, Stockton DW, Peng J, Mardon G, Chen R, Lupski JR. " " Hum. Genet.. 2011 Mar ; 129 (3) : 319-27.
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McClard CK, Kochukov MY, Herman I, Liu Z, Eblimit A, Moayedi Y, Ortiz-Guzman J, Colchado D, Pekarek B, Panneerselvam S, Mardon G, Arenkiel BR.. " " J Neurosci.. 2018 Feb 7; 38 (6) : 1443-1461.
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Schneider-Gädicke A, Beer-Romero P, Brown LG, Mardon G, Luoh SW, Page DC. " " Nature. 1989 Dec 7; 342 (6250) : 708-11.
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Iyer J, Wang Q, Le T, Pizzo L, Grönke S, Ambegaokar SS, Imai Y, Srivastava A, Troisí BL, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Lu B, Kumar JP, Girirajan S.. " " G3 (Bethesda). 2016 May 3; 6 (5) : 1427-37.
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Frankfort BJ, Mardon G. " " Development. 2002 Mar ; 129 (6) : 1295-306.
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Jusiak B, Karandikar UC, Kwak SJ, Wang F, Wang H, Chen R, Mardon G. " " PLoS One. 2014 Feb 25; 9 (2) : e89695.
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Domingos PM, Brown S, Barrio R, Ratnakumar K, Frankfort BJ, Mardon G, Steller H, Mollereau B. " " Dev. Biol.. 2004 Sep 1; 273 (1) : 121-33.
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H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, et al. " " Science. 2014 Jun 20; 344 (6190) : 1346-8.
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Pappu KS, Mardon G.. " " Int J Dev Biol. 2004 ; 48 (8-9) : 913-24.
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Jiang Y, Scott KL, Kwak SJ, Chen R, Mardon G. " " Oncogene. 2011 Jul 21; 30 (29) : 3248-60.
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Frankfort BJ, Pepple KL, Mamlouk M, Rose MF, Mardon G. " " Genesis. 2004 Apr ; 38 (4) : 182-94.
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Frankfort BJ, Mardon G. " " Development. 2004 Feb ; 131 (3) : 563-70.
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Frankfort BJ, Nolo R, Zhang Z, Bellen H, Mardon G. " " Neuron. 2001 Nov 8; 32 (3) : 403-14.
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Simon MA, Carthew RW, Fortini ME, Gaul U, Mardon G, Rubin GM. " " Cold Spring Harb. Symp. Quant. Biol.. 1992 ; 57 : 375-80.
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Chen R, Halder G, Zhang Z, Mardon G. " " Development. 1999 Feb ; 126 (5) : 935-43.
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Atkins M, Mardon G. " " Dev. Dyn.. 2009 Sep ; 238 (9) : 2139-48.
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Eblimit A, Nguyen TM, Chen Y, Esteve-Rudd J, Zhong H, Letteboer S, Van Reeuwijk J, Simons DL, Ding Q, Wu KM, Li Y, Van Beersum S, Moayedi Y, Xu H, Pickard P, Wang K, Gan L, Wu SM, Williams DS, Mardon G, Roepman R, Chen R.. " " Hum Mol Genet. 2015 Mar 15; 24 (6) : 1584-601.
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Tavsanli BC, Ostrin EJ, Burgess HK, Middlebrooks BW, Pham TA, Mardon G. " " Dev. Biol.. 2004 Aug 1; 272 (1) : 231-47.
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Heanue TA, Reshef R, Davis RJ, Mardon G, Oliver G, Tomarev S, Lassar AB, Tabin CJ. " " Genes Dev.. 1999 Dec 15; 13 (24) : 3231-43.
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Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK.. " " PLoS Genet. 2014 Jan ; 10 (1) : e1004055.
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Mlotshwa BC, Mwesigwa S, Mboowa G, Williams L, Retshabile G, Kekitiinwa A, Wayengera M, Kyobe S, Brown CW, Hanchard NA, Mardon G, Joloba M, Anabwani G, Mpoloka SW.. " " Genet Med. 2017 Jul ; 19 (7) : 826-833.
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Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG. " " Trends Endocrinol. Metab.. 2010 Jan ; 21 (1) : 41-9.
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Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG.. " " Cancer Res. 2015 May 15; 75 (10) : 1992-2004.
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Anderson AE, Karandikar UC, Pepple KL, Chen Z, Bergmann A, Mardon G. " " Development. 2011 May ; 138 (10) : 1957-66.
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Kaplan JM, Mardon G, Bishop JM, Varmus HE. " " Mol. Cell. Biol.. 1988 Jun ; 8 (6) : 2435-41.
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Martini SR, Roman G, Meuser S, Mardon G, Davis RL. " " Development. 2000 Jun ; 127 (12) : 2663-72.
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Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG. " " Cell. 1987 Dec 24; 51 (6) : 1091-104.
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Mardon G, Page DC. " " Cell. 1989 Mar 10; 56 (5) : 765-70.
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Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon G. " " Development. 2008 Dec ; 135 (24) : 4071-9.
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Wang X, Wang H, Cao M, Li Z, Chen X, Patenia C, Gore A, Abboud EB, Al-Rajhi AA, A Lewis R, Lupski JR, Mardon G, Zhang K, Muzny D, Gibbs RA, Chen R. " " Hum. Mutat.. 2011 Dec ; 32 (12) : 1450-9.
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Pesah Y, Burgess H, Middlebrooks B, Ronningen K, Prosser J, Tirunagaru V, Zysk J, Mardon G. " " Genesis. 2005 Apr ; 41 (4) : 154-9.
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Yeung K, Wang F, Li Y, Wang K, Mardon G, Chen R. " Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.. " Nucleic Acids Res.. 2018 ; 46 : 11743-11758.

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