Positions
- Assistant Professor
-
Pediatrics
Neurology and Developmental Neuroscience
ÌÇÐÄvlogÃÛÌÒ of Medicine
Houston, TX, US
Addresses
- Blue Bird Circle Clinic for Pediatric Neurology (Hospital)
-
TCH-Clinical Care Center
Room: TXCL-1250
Houston, TX, 77030
United States
Phone: (832) 822-1750
- Jan and Dan Duncan Neurological Research Institute (Lab)
-
1250 Moursund St., Suite 925
Houston, TX, 77030
United States
Phone: (832) 824-8957
holder@bcm.edu
- Jan and Dan Duncan Neurological Research Institute (Office)
-
1250 Moursund St., Suite 925
Houston, TX, 77030
United States
Phone: (832) 824-8957
holder@bcm.edu
- Texas Children's Hospital, Clinical Care Center (Clinic)
-
6701 Fannin St. Ste 1250
Houston, TX, 77030
United States
Phone: (832) 822-1750
Education
- BA from Johns Hopkins University
- 05/1996 - Baltimore, Maryland, United States
- Biology
- MD from University Of Texas Southwestern
- 06/2005 - Dallas, Texas, United States
- PhD from University Of Texas Southwestern
- 06/2005 - Dallas, Texas, United States
- Genetics and Development
- Residency at ÌÇÐÄvlogÃÛÌÒ Of Medicine
- 06/2009 - Houston, Texas, United States
- Pediatrics
- Residency at ÌÇÐÄvlogÃÛÌÒ Of Medicine
- 06/2012 - Houston, Texas, United States
- Child Neurology
- Post-Doctoral Fellowship at University of California San Francisco
- 06/2007 - San Francisco, California, United States
- Neurogenetics
Certifications
- American Board of Psychiatry ad Neurology
- Board certification in Neurology with Special Qualification in Child Neurology
- #P5534 (02/08/2013 - 02/28/2016)
- Texas Medical Board
Honors & Awards
- Chao Physician-Scientist Award
- ÌÇÐÄvlogÃÛÌÒ of Medicine (07/2013 - 06/2014)
- Director, Medical Advisory Board
- Bridge the Gap - SYNGAP education and research foundation (01/2015)
- Philip R. Dodge Young Investigator Award
- Child Neurology Society (10/2015)
Professional Statement
In the next 20 years, we will discover individualized therapies for neurodevelopmental disorders. This is the mission statement of my lab. We are using a spectrum of approaches to achieve this goal, from cell-based screens to mouse models of disease to neurons derived from in induced pluripotent stem cells (iPSCs). My ultimate goal is to translate the findings from the lab back to the clinic to improve quality of life for children with neurodevelopmental disorders.
Websites
Professional Development
- Co-organizer
- Conference (Organizer, 2015)
- Sponsor: Phelan-McDermid Syndrome Foundation
Selected Publications
-
Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HY. " " Nature. 2013 Nov 7; 503 (7474) : 72-7.
Pubmed PMID: . -
He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL, Rossner MJ, Nishino S, Fu YH. " " Science. 2009 Aug 14; 325 (5942) : 866-70.
Pubmed PMID: . -
Holder JL Jr, Butte NF, Zinn AR. " " Hum Mol Genet.. 2000 Feb 1; 9 (1) : 101-8.
Pubmed PMID: . -
Holder JL, Wilfong AA. " " Expert Opin Pharmacother. 2011 Nov ; 12 (16) : 2573-81.
Pubmed PMID: .
Memberships
- Child Neurology Society
- Member
- American Academy of Neurology
- Member
- American Academy of Pediatrics
Funding
-
Clinical Scientist Development Award
- (07/01/2017 - 06/30/2021)
- Grant funding from Doris Duke Charitable Foundation
- Identify genetic modifiers of SYNGAP1 and validate in human neurons.
-
Harnessing post-translational regulation of SHANK3 as a boosting strategy for Phelan-McDermid syndrome
#R01NS120980 - (05/31/2021 - 03/30/2026)
- Grant funding from NINDS (NIH)
-
Identifying genetic modifiers of Sulfamidase protein stability
#R03NS120078 - (10/01/2020 - 09/30/2022)
- Grant funding from NINDS (NIH)
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