Jonathan Marcus Fogg

Jonathan Marcus Fogg, Ph.D.

Senior Staff Scientist

(713) 798-6248

Email

fogg@bcm.edu

Positions

Senior Staff Scientist: Virol & Micro: Zechiedrich
��vlog�� of Medicine
Houston, TX, US

Education

Postdoctoral Training at ��vlog�� of Medicine: 11/2011 - Houston, Texas, United States

Postdoctoral Training at University of California at Santa Barbara: 06/2005 - Santa Barbara, California, United States

BS from University of Leeds: 07/1996 - Leeds, United Kingdom

PhD from University of Dundee: 07/2001 - Dundee, United Kingdom

Professional Statement

Throughout my research I have focused on how DNA is able to be an active participant in its transactions. DNA structure, particularly the structure of supercoiled DNA, is much more variable and dynamic than many people realize. This insight has allowed me to contribute to a better understanding of protein-DNA interactions and DNA itself. In the process, I have also developed unique DNA tools that are proving to be extremely useful, not only for basic research, but also clinical applications. I have developed a patented protocol to generate milligram quantities of supercoiled minicircle DNA, as small as 250 bp. Using these DNA minicircles, I precisely determine the supercoiling dependence of topoisomerase binding and additionally elucidate the mechanism through which DNA topoisomerases recognize their supercoiled DNA substrate and determine where to act. These minicircles also provide a unique insight into the structure of supercoiled DNA, including previously unappreciated differences between overwound and underwound DNA. Throughout my career I have collaborated with researchers from many disciplines including biochemistry, biophysics, physics, mathematics, structural biology, and medicine.

Selected Publications

Wang, Q.; Irobalieva R.N.; Chiu W., Schmid M.F.; Fogg J.M.; Zechiedrich L.; Pettitt B.M.. " " Nucleic Acids Res.. 2017 Jul 27; 45 (13) : 7633-7642.
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Fogg J.M.; Catanese D.J. Jr.; Randall G.L.; Swick M.C.; Zechiedrich L.. " " Mathematics of DNA Structure, Function and Interactions. 2009 ; 150 : 73-121.
Fogg, J.M.; Randall, G.L.;Pettitt, B.M.;Sumners, D.W.; Harris, S.A.; and Zechiedrich, L... " " Quarterly Review of Biophysics. 2012 ; 45 : 257-299.
Fogg J.M.; Kvaratskhelia, M.; White M.F.; Lilley D.M.J.. " " J. Mol. Biol.. 2001 Nov 3; 313 (4) : 751-764.
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Fogg D.M.J.; Lilley D.M.J.. " " Biochemistry. 2000 Dec 26; 39 (51) : 16125-16134.
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Fogg J.M.; Kolmakova N.; Rees I.; Magonov S.; Hansma H.; Perona J.J.; Zechiedrich E.L.. " " J Phys Condens Matter. 2006 Mar 24; 18 (14) : S145-S159.
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Kvaratskhelia M.; Wardleworth B.N.; Bond C.S.; Fogg J.M.; Lilley D.M.J.; White M.F.. " " 2002 Jan 25; 277 (4) : 2992-2996.
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Fogg J.M.; Schofield M.J.; White M.F.; Lilley D.M.J.. " " Biochemistry. 1999 Aug 31; 38 (35) : 11349-11358.
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Hiller D.A.; Fogg J.M.; Martin A.M.; Beechem J.M.; Reich N.O.; Perona J.J.. " " Biochemistry. 2003 Dec 16; 42 (49) : 14375-14385.
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Irobalieva, R.N.; Fogg J.M.; Catanese D.J. Jr.; Sutthibutpong, T.; Chen M.; Barker A.K.; Ludtke S.J.; Harris S.A.; Schmid M.F.; Chiu W.; Zechiedrich L.. " " Nat Commun.. 2015 Oct 12; 6 : 8440.
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Catanese D.J. Jr.; Fogg J.M.; Schrock D.E. 2nd.; Gilbert B.E.; Zechiedrich L.. " " Gene Ther.. 2012 Jan ; 19 (1) : 94-100.
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Déclais A.C.; Fogg J.M.; Freeman A.D.; Coste F.; Hadden J.M.; Phillips S.E.; Lilley D.M.J.. " " EMBO J.. 2003 Mar 17; 22 (6) : 1398-1409.
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Bizard, A.H.; Yang, X.; Débat, H.; Fogg, J.M.; Strick, T.R.; Garnier, F.; Nadal, M.. " " Nucleic Acids Res.. 2018 Jan 25; 46 (2) : 861-872.
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Zhao, N.; Fogg, J.M.; Zechiedrich L.; Yu Z.. " " Gene Ther.. 2011 ; 18 (3) : 220-224.
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Fogg J.M.; Schofield M.J.; Déclais A.C.; Lilley D.M.J.. " " Biochemistry. 2000 Apr 11; 39 (14) : 4082-4089.
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Fogg, J.M., Judge, A.K., Stricker, E., Chan, H.L., Zechiedrich, L.. " " Nat. Commun.. 2021 Sep ; 12 (1) : 5683.
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Waszkiewicz, R., Ranasinghe, M., Fogg, J.M., Catanese, D.J., Ekiel-Jeżewska, M.L., Lisicki, M., Demeler, B., Zechiedrich, L. Szymczak, P.. " " Nucleic Acids Res.. 2023 May ; 51 (8) : 4027-4042.
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Ranasinghe, M., Fogg, J.M., Catanese Jr., D.J., Zechiedirch, L., Demeler, B.. " " Eur Biophys J.. 2023 Jul ; 52 : 267-280.
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Arévalo-Soliz, L.M., Hardee, C.L., Fogg, J.M., Corman, N.R., Noorbakhsh, C., Zechiedrich, L.. " " Cell Gene Ther Insights. 2020 Nov ; 6 (10) : 1489-1505.
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Zechiedrich, L., Fogg, J.M.. " " Technol Innov .. 2019 Aug ; 20 (4) : 427-439.
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