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Michael Francis Wangler

Wangler

Michael Francis Wangler, M.D.

Associate Professor

(832) 822-4280

Positions

Associate Professor
Molecular and Human Genetics
ÌÇÐÄvlogÃÛÌÒ of Medicine
Houston, TX, US
Faculty Member
Graduate Programs in Development, Disease Models & Therapeutics and Genetics & Genomics
ÌÇÐÄvlogÃÛÌÒ of Medicine

Addresses

Texas Children's Genetics Clinic (Clinic)
Texas Children's Clinical Care Center
6701 Fannin St., 16th Floor
Houston, TX, 77030
United States
Phone: (832) 822-4280
Duncan Neurological Research Institute (Lab)
Room: DNRI-1050
Houston, TX, 77030
United States
Phone: (832) 822-1240
michael.wangler@bcm.edu

Education

MD from ÌÇÐÄvlogÃÛÌÒ Of Medicine
Houston, TX, United States
Internship at ÌÇÐÄvlogÃÛÌÒ Of Medicine Affiliate Hospitals
Houston, TX, United States
Pediatrics
Residency at ÌÇÐÄvlogÃÛÌÒ Of Medicine Affiliate Hospitals
Houston, TX
Pediatrics
Residency at ÌÇÐÄvlogÃÛÌÒ Of Medicine Affiliate Hospitals
Houston, TX
Clinical Genetics

Professional Interests

  • Pediatric genetics
  • Peroxisomal disorders

Professional Statement

Molecular and Developmental Mechanisms of Mendelian Disorders
Our lab studies rare human disease phenotypes in order to gain insight into general principles of human health. Methods include clinical studies in rare disease, genomics and model organism genetics particularly Drosophila melanogaster. We are currently using Drosophila to study Mendelian disorders and their underlying genetic and developmental mechanisms in two major efforts:

1) Model Organisms and the Molecular Pathogenesis of Mendelian Disorders: We use Drosophila models for diagnostic paradigms. We are part of the Model Organisms Screening Center (MOSC) for the Undiagnosed Diseases Network (UDN). We have also started a similar effort in underserved populations called Community TEXOME.

2) Mendelian Disorders of the Peroxisome and Organelle Dynamics: Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells. We use clinical and Drosophila studies in the elucidation of mechanisms of Peroxisomal Biogenesis Disorders- Zellweger Spectrum disorders (PBD-ZSD). These diseases are expanding from autosomal recessive disorders to a broad range of human diseases related to peroxisomes.

Selected Publications

  • Jangam S, Briere L, Jay K, Andrews J, Walker M, High F, Yamamoto S, Sweetser D, Wangler MF*. " " Submitted. Available on MedRxiv. 2023 ;
  • Andrews JC, Mok JW, Kanca O, Jangam S, Tifft C, Macnamara EF, Russell BE, Wang LK; Undiagnosed Diseases Network; Nelson SF, Bellen HJ, Yamamoto S, Malicdan MCV, Wangler MF*.. " " Genet Med.. 2023 Mar 31; (100833)
    Pubmed PMID: .
  • Lyons-Warren AM, Wangler MF, Wan YW. " " Int J Mol Sci.. 2023 ; 23 (21) : 13030.
    Pubmed PMID: .
  • Huang Y, Lemire G, Briere LC, Liu F, Wessels MW, Wang X, Osmond M, Kanca O, Lu S, High FA, Walker MA, Rodan LH; Undiagnosed Diseases Network; Care4Rare Canada Consortium, Wangler MF, Yamamoto S, Kernohan KD, Sweetser DA, Boycott KM, Bellen HJ. " " Am J Hum Genet.. 2022 ; 109 (11) : 2092.
    Pubmed PMID: .

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