Positions
- Professor
-
Integrative Physiology/Pautler
ÌÇÐÄvlogÃÛÌÒ of Medicine
Houston, TX, US
Education
- Ph.D. from Carnegie Mellon University
- 01/1999 - Pittsburgh, PA, United States
- B.S. from Colorado State University
- 01/1993 - Fort Collins, CO, United States
Professional Interests
- Gene Expression
- Axonal Transport
- Biomedical Imaging
- Alzheimer's Disease
- Neurophysiology
Professional Statement
Dr. Pautler develops and applies methodologies that permit high- resolution images of the structure and function of the brain in intact, living animals. Her current research efforts build upon the new technique that she developed known as Manganese Enhanced MRI (MEMRI) neuronal tract tracing. Manganese ion, Mn2+, is a calcium analogue and can enter neurons through calcium (Ca2+) channels. Furthermore, Mn2+ is transported along microtubules via fast axonal transport and is also paramagnetic, rendering it MRI detectable in spin-lattice (T1)-weighted MRI images. It is therefore possible to utilize MRI to repeatedly measure dynamic changes in signal intensity, reflective of fast axonal transport of Mn2+ ion, within the same animal before and during disease progression. One main project in Dr. Pautler's lab involves utilizing MEMRI to longitudinally elucidate in vivo changes in axonal transport rates in the central nervous system of mouse models of Alzheimer's Disease (AD) as symptoms evolve. Axonal transport deficits have been observed in flies and cultured rodent neurons exposed to excess amyloid precursor protein (APP) or amyloid-beta, but neither the molecular basis of the transport deficit nor the temporal relationship of the transport deficit and the acquisition of AD are known.
Selected Publications
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Inoue T1, Griffin DM2, Huq R1, Samuel EL3, Ruano SH1, Stinnett G1, Majid TJ2, Beeton C1,2, Tour JM4, Pautler RG5,6.. " " NMR Biomed. 2016 Oct ; 29 ((10)) : 1436-44.
Pubmed PMID: . -
Bitner BR, Marcano DC, Berlin JM, Fabian RH, Cherian L, Culver JC, Dickinson ME, Robertson CS, Pautler RG, Kent TA, Tour JM. " " ACS Nano. 2012 Sep 25; 6 (9) : 8007-14.
Pubmed PMID: . -
Dustin D1, Hall BM2, Annapragada A3, Pautler RG4.. " " Transl Res.. 2016 Sep ; 175 : 37-53.
Pubmed PMID: . -
Majid T, Ali YO, Venkitaramani DV, Jang MK, Lu HC, Pautler RG.. " " Neuroimage Clin. 2014 Mar 31; 4 : 711-7.
Pubmed PMID: .
Memberships
- ISMRM
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