Thomas Garcia

Thomas Garcia, PhD, HCLD (ABB)

Assistant Professor

(713) 798-3745

Email

thomas.garcia@bcm.edu

Positions

Assistant Professor: Department of Pathology & Immunology
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Assistant Professor: Scott Department of Urology
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Clinical Laboratory Director: Advanced Reproductive And Urologic Procedures Laboratory
Scott Department of Urology
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Clinical Laboratory Director: Special Procedures Laboratory
Scott Department of Urology
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Clinical Laboratory Director: Sperm Bank
Scott Department of Urology
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Education

BS from Florida State University: 08/2003 - Tallahassee, Florida, United States

PhD from University of Illinois at Urbana-Champaign: 05/2009 - Urbana, Illinois, United States

Postdoctoral Fellowship at University of Texas MD Anderson Cancer Center: 08/2012 - Houston, Texas, United States

Certifications

High-complexity Clinical Laboratory Director (HCLD): American Board of Bioanalysis (ABB)

Professional Interests

Identifying new genetic causes of male infertility
Elucidating the molecular mechanisms underlying sperm development, maturation, and function
Investigating novel male reproductive tract-specific genes as contraceptive targets

Websites

Bioinformatics & Genomics Tools: A suite of novel, open-source, command-line tools for advanced bioinformatics and genomic analysis. Developed by Dr. Garcia with support from the Male Contraceptive Initiative and Eunice Kennedy Shriver NICHD, these resources are designed to accelerate research into the genetic basis of reproduction and disease.

Mammalian Reproductive Genetics Database (MRGDv2): A modernized data resource for exploring complex gene expression patterns in reproductive biology. Spearheaded by the Garcia lab and supported by the NICHD, this platform integrates legacy microarray data with nearly a thousand contemporary RNA-seq datasets, empowering researchers to identify novel targets for male contraception and study the genetics of fertility and disease.

Selected Publications

Kent K, Nozawa K, Parkes R, Dean L, Daniel F, Leng M, Jain A, Malovannaya A, Matzuk MM, and Garcia TX. " " Proc Natl Acad Sci. 2024 Dec 12; 121 (51)
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Sutton CM, Umezu K, Mashiko D, Ikawa M, Larina IV, Garcia TX, Matzuk MM. " " Sci Rep. 2025 Aug 5; 15 (1) : 28657.
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Kent K, Nozawa K, Jain A, Malovannaya A, Garcia TX, Matzuk MM. " " Biol Reprod. 2025 Mar 28; (ioaf069)
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Garcia TX, Matzuk MM. " " Mol Reprod Dev. 2024 Oct ; 91 (10)
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Parkes R and Garcia TX. " " Expert Rev Proteomics. 2024 Apr ; 21 (4) : 181-203.
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Kent K, Nozawa K, Sutton C, Daniel F, Ikawa M, Garcia TX, Matzuk MM. " " Andrology. 2024 Mar ; 12 (3) : 682-697.
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Suzuki A, Yabuta N, Shimada K, Mashiko D, Tokuhiro K, Oyama Y, Miyata H, Garcia TX, Matzuk MM, Ikawa M. " " J Reprod Immunol. 2024 Jun ; 163
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Tan Z and Garcia TX. " " PNAS. 2023 Feb 15; 120 (8) : e2221758120.
Sutton C, Nozawa K, Kent K, Saltzman A, Leng M, Nagarajan S, Malovannaya A, Ikawa M, Garcia TX, Matzuk MM. " " Sci Rep. 2023 Jul 14; 13 (1) : 11374.
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Nozawa K, Garcia TX, Kent K, Leng M, Jain A, Malovannaya A, Yuan F, Yu Z, Ikawa M, Matzuk MM. " " Andrology. 2023 Jul ; 11 (5) : 826-839.
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Nozawa K, Fujihara Y, Devlin DJ, Deras RE, Kent K, Larina IV, Umezu K, Yu Z, Sutton CM, Ye Q, Dean LK, Emori C, Ikawa M, Garcia TX, Matzuk MM. " " BMC Biol. 2022 Jul 13; 20 (1) : 161.
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Oyama Y, Miyata H, Shimada K, Fujihara Y, Tokuhiro K, Garcia TX, Matzuk MM, Ikawa M. " " Asian J Androl. 2021 Jul 16;
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Robertson MJ, Kent K, Tharp N, Nozawa K, Dean L, Mathew M, Grimm SL, Yu Z, Légaré C, Fujihara Y, Ikawa M, Sullivan R, Coarfa C, Matzuk MM, Garcia TX. " " BMC Biol. 2020 Aug 19; 18 (1) : 103.
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Kent K, Johnston M, Strump N, and Garcia TX. " " Front Cell Dev Biol. 2020 Feb 26;
Holcomb RJ, Oura S, Nozawa K, Kent K, Yu Z, Robertson MJ, Coarfa C, Matzuk MM, Ikawa M, Garcia TX. " " Biol Reprod. 2020 Feb 12; 102 (1) : 84-91.
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Sun J, Lu Y, Nozawa K, Xu Z, Morohoshi A, Castaneda JM, Noda T, Miyata H, Abbasi F, Shawki HH, Takahashi S, Devlin DJ, Yu Z, Matzuk RM, Garcia TX, Matzuk MM, Ikawa M. " " Biol Reprod. 2020 Aug 4; 103 (2) : 183-194.
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Park S, Shimada K, Fujihara Y, Xu Z, Shimada K, Larasati T, Pratiwi P, Matzuk RM, Devlin DJ, Yu Z, Garcia TX, Matzuk MM, Ikawa M. " " Biol Reprod. 2020 Aug 4; 103 (2) : 195-204.
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Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Meistrich ML, Shetty G, Hofmann MC. " " FASEB J. 2019 Apr 16; fj201802361R.
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Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M. " " Biol Reprod. 2019 Aug 1; 101 (2) : 501-511.
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Parekh P, Garcia TX, Hofmann MC. " " Reproduction. 2019 Jan 1; pii: REP-18-0239.R2.
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Garcia TX, Parekh P, Kow S, Hofmann MC. " " Stem Cells Dev. 2017 Apr 15; 26 (8) : 585-598.
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Garcia TX, Farmaha JK, Kow S, Hofmann MC. " " Development. 2014 Dec ; 141 (23) : 4468-78.
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Garcia TX, Costa GMJ, França LR, Hofmann MC. " " Reprod Toxicol. 2014 Jun ; 45 : 59-70.
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Garcia TX, Hofmann MC. " " Cell Cycle. 2013 Aug 15; 12 (16) : 2538-45.
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Garcia TX, DeFalco T, Capel B, Hofmann MC. " " Dev Biol. 2013 May 1; 377 (1) : 188-201.
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Garcia T, Hofmann MC. " " Methods Mol Biol. 2012 ; 825 : 31-44.
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Lin Z, Witschas K, Garcia T, Chen RS, Hansen JP, Sellers ZM, Kuzmenkina E, Herzig S, Best PM. " " J Physiol. 2008 Nov 15; 586 (22) : 5349-66.
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Memberships

Society for the Study of Reproduction: Member

American Society for Human Genetics: Member

American Urological Association: Member

American Association of Bioanalysts: Member

Funding

Search for new genes involved in male infertility through novel approaches #R01 HD106056: (02/22/2022 - 11/30/2026); Grant funding from National Institutes of Health

Third-generation sequencing of infertile men to confirm male contraceptive target feasibility: (02/01/2022 - 01/31/2024); Grant funding from Male Contraceptive Initiative

Mammalian Reproductive Genetics Database V2: (05/01/2021 - 04/30/2022); Grant funding from Male Contraceptive Initiative

Functional genomics and proteomics to reveal reproductive-tract specific proteins #R01 HD095341: (04/01/2018 - 03/31/2021); Grant funding from National Institutes of Health

Intellectual Property

: Method Patent #US 8,299,211 B2 (Approved); This method and composition patent discloses methods and compositions involving short peptides capable of regulating calcium channel function, particularly for applications in modulating calcium current in mammalian cells. The patent includes embodiments of peptides, nucleic acids encoding these peptides, and pharmaceutical compositions for therapeutic use.; Co Inventors: Philip M. Best, Ren-Shiang Chen, Zuojun Lin, Thomas Garcia

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