ÌÇÐÄvlogÃÛÌÒ

Email

xiangz@bcm.edu

Positions

Director

Lester and Sue Smith Breast Center

William T. Butler, M.D., Endowed Chair for Distinguished Faculty

ÌÇÐÄvlogÃÛÌÒ of Medicine

Professor

Molecular and Cellular Biology
ÌÇÐÄvlogÃÛÌÒ of Medicine
Houston, TX, US

Member

Dan L. Duncan Comprehensive Cancer Center

Education

Post-Doctoral Fellowship at Memorial Sloan Kettering Cancer Center

06/2011 - New York, New York, United States

PhD from Columbia University

05/2006 - New York, New York, United States

BS from Fudan University

01/2000 - Shanghai, China, People's Rep

Honors & Awards

Era of Hope Scholar

Department of Defense Congressionally Directed Medical Research Programs, Breast Cancer Research Program (03/2016 - 03/2021)

NIH Pathway to Independence Award (K99/R00)

National Cancer Institute (09/2010 - 09/2014)

Career Catalyst Research Award

Susan G. Komen Foundation (09/2014 - 08/2017)

Excellence in Research

Department of Molecular and Cellular Biology, BCM (08/2016)

Michael E. DeBakey Award for Excellence in Research

ÌÇÐÄvlogÃÛÌÒ of Medicine (05/2018)

Sue Eccles Young Investigator Award

Metastasis Research Society (08/2018)

Laura Zisken Prize

Stand Up To Cancer (01/2020 - 01/2021)

Leadership Award

Theresa's Research Foundation (10/2016)

Websites

Selected Publications

• Xiang H.-F. Zhang*, X Jin*, S Malladi, YH Wen, E Brogi, M Smid, JA Foekens, and J Massagué.. " " Cell. 2013 ; 154 (5) : 1060-73.
  Pubmed PMID: .
• H Wang; C Yu; X Gao; T Welte; A Muscarella; L Tian; J Liu; H Zhao; Z Zhao; J Tao; B Lee; TF Westbrook; STC Wong; JM. Rosen; CK Osborne; Xiang H.-F. Zhang. " " Cancer Cell. 2015 Feb 9; 27 (2) : 193-210.
• T Welte, IS Kim, L Tian, X Gao, H Wang, J Li, XB Holdman, JI Herschkowitz, A Pond, G Xia, S Kurley, T Nguyen, L Liao, LE Dobrolecki, Q Mo, DP Edwards, S Huang, L Xin, J Xu, Y Li, MT Lewis, T Wang, TF Westbrook, JM Rosen*, and Xiang H.-F. Zhang*. " " Nature Cell Biology. 2016 Jun ; 18 : 632-644.
• L Tian, A Goldstein, H Wang, IS Kim, HC Lo, T Welte, K Sheng, L Dobrolecki, X Zhang, N Putluri, T Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, C Zong, WK Decker, MT Lewis, and Xiang H.-F. Zhang. " " Nature. 2017 Apr 3; 544 (7649) : 250-254.
• H Wang, L Tian, A Goldstein, HC Lo, J Liu, K Sheng, G Zbigniew, F Stossi, C Zong, Z Li, MA Mancini and Xiang H.-F. Zhang. " " Nature Communications. 2017 ; 8 (15045) : DOI: 10.1038/ncomms15045.
• H Wang, L Tian, J Liu, A Goldstein, I Bado, W Zhang, BR Arenkiel, Z Li, M Yang, S Du, H Zhao, DR Rowley, STC Wong, Z Gugala, and Xiang H.-F. Zhang. " " Cancer Cell. ; 34 (5) : 823-839.
• Kim IS, Gao Y, Welte T, Wang H, Liu J, Janghorban M, Sheng K, Niu Y, Goldstein A, Zhao N, Bado I, Lo H-C, ..., Li Y, Mo Q, Westbrook TF, Zong C, Rao A, Sreekumar A, Rosen JM, Zhang XHF. " " Nature Cell Biology. 2019 Sep ; 21 (9) : 1113-1126.
• Lo HC, Xu Z, Kim IS, Pingel B, Aguirre S, Kodali S, Liu J, Zhang W, Muscarella AM, Hein SM, Krupnick AS, Neilsen JR, Paust S, Rosen JM, Wang H, and Xiang H.-F. Zhang. " " Nature Cancer. 2020 ; 1 : 709–722.
• Muscarella MM, Dai W, Mitchell PG, Zhang W, Wang H, Jia L, Stossi F, Mancini MA, Chiu W, and Xiang H.-F. Zhang. " " NPG Breast Cancer. 2020 Sep 7;
• Zhang W*, Bado IL*, Hu J, Wan YW, Wu L, Wang H, Gao Y, Jeong HH, Xu Z, Hao X, Lege BM, AI-Ouran R, Li L, Li J, Yu L, Singh S, Lo H-C, Niu M, Liu J, Jiang W, Li Y, Wong STC, Cheng C, Liu Z, Xiang H.-F. Zhang. " " Cell. 2021 Apr 19; Online ahead of print (*: Equal contribution)
• Bado IL*, Zhang W*, Wang H, Hu J, Sarkar P, Liu J, Zbigniew G, Xu Z, Zhang W, Li L, Wan YW, Wu W, Lo H-C, Kim IS, Singh S, Janghorban M, Muscarella A, Goldstein A, Singh P, Jeong HH, Liu C, Huang S, Schiff R, Gaber MW, Liu Z, Ellis MJ, Xiang H.-F. Zhang. " " Dev. Cell. 2021 Apr 19; 56 (8) : 1100-1117 *: equal contribution.
• Zeru Tian, Ling Wu, Chenfei Yu, Yuda Chen, Zhan Xu , Igor Bado , Axel Loredo , Lushun Wang , Hai Wang , Kuan-Lin Wu , Weijie Zhang , Xiang H.-F. Zhang*, Han Xiao*. " " Sci. Adv.. 2021 Jun 23; 7 (eabf2051) : * Co-senior authors.
• Zhang W, Zhan X, Hao X, He T, Li J, Shen Y, Liu K, Gao Y, Liu J, Edwards DG, Muscarella AM, Wu L, Yu L, Xu L, Chen X, Wu YH, Bado IL, Ding Y, Aguirre S, Wang H, Gugala Z, Satcher RL, Wong STC, Xiang H.-F. Zhang. " " Cancer Discovery. 2023 ; 13 (2) : 474-495.
• Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L, Chan HL, Xu Z, Yu L, Gao Y, Bado I, Michie LN, Rivas CH, Becerra-Dominguez L, Aguirre S, Pingel BC, Wu Y-H, Liu F, Ding Y, Edwards DG, Liu J, ..., Shu-Hsia Chen, Mien-Chie Hung, Bora Lim, Xiang H.-F. Zhang. " " Cell Stem Cell. 2023 ; 30 (5) : 648-664.
• X Hao, Y Shen, J Liu, ..., Ueno NT, Lim B, Xiang H.-F. Zhang. " " Nature Cell Biology. 2024 Nov ; 26 (11) : 1971-83.
• Yu L, Liebenberg K, Shen Y, Liu F, Xu Z, Wu L, Hao X, Zhang W, Chan HL, Wei B, Lorenzi P, Gao Y, Bado I, Dominguez LB, Rivas CH, Aguirre S, Pingel B, Wu, Y-H, Ding Y, Liu J, Edwards DG, Eberlin LS, and Xiang H.-F. Zhang. " " Immunity. 2025 Apr 8; 58 (4) : 909-925.
• Liu F, Ding Y, Xu Z, Hao X, Pan T, Miles G, Wu Y-H, Liu J, Bado IL, Zhang W, Wu L, Gao Y, Yu L, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Shen Y, Hoffman D, Dominguez LB, Rivas CH, Chen X, Wang H, Gugala Z, Satcher RL, Xiang H.-F. Zhang. " " Cell Genomics. 2025 Jul 9; (7) : 100888.
• Yu L, Liu F, Shen Y, Xu Z, Wu L, Ding Y, Hao X, Zhang W, Chan HL, Liu J, Wei B, Lorenzi PL, Gao Y, Becerra-Dominguez L, Rivas CH, Wu, YH, Wang S, Lee T, Li X, Edwards EG, Xiang H.-F. Zhang. " Inflammation- and resolution-programmed myeloid circuits drive dichotomous therapeutic resistance in epithelial and mesenchymal TNBC. " Journal of Clinical Investigation. 2026 ; Accepted
• Xu Z, Liu F, Ding Y, Pan T, Wu Y-H, Han Y, Liu J, Bado IL, Wu L, Gao Y, Hao X, Yu L, Li X, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Wang S, Shen Y, Hoffman D, ..., Kang Y, Gugala Z, Satcher RL, Xiang H.-F. Zhang. " Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization.. " Cell. 2026 ; Accepted

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Memberships

American Association of Cancer Research

Member (01/2012)

Metastasis Research Society

Member (03/2016)

American Association of Immunology

Member (12/2016)