Zheng Sun

Zheng Sun, Ph.D.

Associate Professor

Email

zheng.sun@bcm.edu

Positions

Associate Professor: Department of Medicine, Division of Endocrinology, Diabetes and Metabolism
Department of Molecular and Cellular Biology
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Member: Dan L Duncan Comprehensive Cancer Center
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Houston, Texas, United States

Member: Gulf Coast Center for Precision Environmental Health
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Houston, Texas, United States

Member: Huffington Center on Aging
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Houston, Texas, United States

Member: Texas Medical Center Digestive Diseases Center
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Houston, Texas, United States

Addresses

Alkek Building for Biomedical Research (Office): Room: ABBR-R616
Houston, TX, 77030
United States
Phone: (713) 798-3164
/research/labs/zheng-sun

Education

PhD from University of Arizona: Tucson

Post-Doctoral Fellowship at University of Pennsylvania: Philadelphia

Professional Interests

Epigenomic regulation of energy metabolism and neurocognition by physical exercise, diet, endocrine factors, and the circadian clock.

Professional Statement

What doesn't kill you makes you stronger. Hormesis, the paradoxical beneficial effect of low-dose stressors, can be elicited by reactive oxygen species, chemical toxins, calorie restriction, and physical exercise. Timing is everything in resilience. Intermittent exposure can generate opposite effects compared with continuous exposure. Early-life stress can increase resilience in later life and lack of stress can lead to vulnerability. An initial exposure can elicit an adaptive stress response with long-term epigenomic changes that anticipate subsequent exposures.

We are interested in how energy metabolism and neurocognition are regulated at the epigenomic level by the environmental factors including diet, physical exercise, hormones, and the circadian clock. We apply multi-omics approaches, optogenetics, chemogenetics, single-cell techniques, genome editing, novel viral vectors, metabolic tracing, neuronal tracing, and neurobehavioral tests.

Keywords: circadian clock, epigenome, nuclear hormone receptor, diabetes, heart failure, autism, neurodegenerative disease

Websites

Section of Endocrinology, Diabetes and Metabolism

Sun Lab

Selected Publications

Peng F, Li X, Xiao F, Zhao R, Sun Z.. " Circadian clock, diurnal glucose metabolic rhythm, and dawn phenomenon. " Trends Neurosci.. 2022 ; 45 (6) : 471-482.
Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z.. " " Circulation. 2022 ; 145 (6) : 448-464.
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Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z.. " Rev-erb in GABAergic neurons controls diurnal hepatic insulin sensitivity. " Nature. 2021 ; 592 (7856) : 763-767.
Gong Y, Xue Y, Li X, Zhang Z, Zhou W, Marcolongo P, Benedetti A, Mao S, Han L, Ding G, Sun Z.. " Inter- and trans-generational effects of paternal exposure to inorganic arsenic. " Adv. Sci. 2021 ; 8 (7) : 2002715.
Kong Y, Zhou W, Sun Z. " " Mol Psychiatry. 2020 ; 161 (8) : bqaa083.
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Zhou W, He Y, Rehman AU, Kong Y, Hong Y, Ding G, Yalamanchili HK, Wan Y-W, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O’Driscoll M, Morton JEV, DDD study, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, Sun Z. " " Nat Neurosci. 2019 ; 22 (2) : 205-217.
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Li X, Yang T, Sun Z.. " " Trends Endocrinol Metab. 2019 ; (19)30174-2
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Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z. " " Nat Med. 2017 ; 23 (2) : 223-234.
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Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA. " " Science. 2015 ; 348 (6242) : 1488-92.
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Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA. " " Cell Metab. 2016 ; 24 (6) : 863-874.
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Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA.. " " Cell. 2014 ; 159 (5) : 1140-52.
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Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA. " " Mol Cell. 2013 ; 52 (6) : 769-82.
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Sun Z, Lazar MA. " " Trends Endocrinol Metab. 2013 ; 24 (1) : 4-12.
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Sun Z, Feng D, Everett LJ, Bugge A, Lazar MA. " " Cold Spring Harb Symp Quant Biol. 2011 ; 76 : 49-55.
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Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Liu XS, Lazar MA. " " Science. 2011 ; 331 (6022) : 1315-9.
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Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. " " Nat Med. 2012 ; 18 (6) : 934-42.
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You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA. " " Nat Struct Mol Biol. 2013 ; 20 (2) : 182-7.
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Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. " " J Biol Chem. 2011 ; 286 (38) : 33301-9.
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Sun Z, Wu T, Birch CM, Zhang DD. " " Mol Cell Biol. 2011 ; 31 (9) : 1800-11.
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Sun Z, Chin YE, Zhang DD. " " Mol Cell Biol. 2009 ; 29 : 2658-72.
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Sun Z, Zhang S, Chan JY, Zhang DD. " " Mol Cell Biol. 2007 ; 27 : 6334-49.
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